Acute Kahweol Treatment Attenuates Traumatic Brain Injury Neuroinflammation and Functional Deficits

Nutrients

JhihSyuan Lin¹  Hung-Fu Lee¹  Che-Feng Chang² 

[1] Department of Neurosurgery, Cheng Hsin General Hospital, Taipei 11220, Taiwan;Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan;

关键词: coffee;    coffee diterpene kahweol;    traumatic brain injury;    neuroinflammation;    leukocyte infiltration;    innate immunity;   

DOI  :  10.3390/nu11102301

来源: DOAJ

【 摘 要 】

Traumatic brain injury (TBI) affects millions worldwide with devastating long-term effects on health and cognition. Emerging data suggest that targeting the immune response may offer promising strategies to alleviate TBI outcomes; kahweol, an anti-inflammatory diterpene that remains in unfiltered coffee, has been shown to be beneficial in neuronal recovery. Here, we examined whether kahweol could alleviate brain trauma-induced injury in a mouse model of TBI and its underlying mechanisms. TBI was induced by controlled cortical impact (CCI) and various doses of kahweol were intraperitoneally administered following injury. Contusion volume, brain edema, neurobehavioral deficits, and protein expression and activity were evaluated in both short-term and long-term recovery. We found that kahweol treatments significantly reduced secondary brain injury and improved neurobehavioral outcomes in TBI mice. These changes were accompanied by the attenuation of proinflammatory cytokine secretion, decreased microglia/macrophage activation, and reduction of neutrophil and leukocyte infiltration. In addition, continuous kahweol treatment further improved short-term TBI outcomes compared to single-dosage. Collectively, our data showed that kahweol protects against TBI by reducing immune responses and may serve as a potential therapeutic intervention for TBI patients.

【 授权许可】

Unknown