A panel of necroptosis-related genes predicts the prognosis of pancreatic adenocarcinoma

Translational Oncology

Xin Zhang¹  Qi Liu²  Qining Guo²  Yifeng Wang²  Tingting Li²  Ziqi Shang²  Mengjiao Zhang²  Yi Zhang²  Zhengdong Luo²  Yanli Zhang³  Lei Wang⁴ 

[1] Corresponding authors.;Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan 250012, China;Department of Clinical Laboratory, Shandong Provincial Third Hospital, Jinan 250031, China;Department of Orthodontics, Qilu Hospital of Shandong University, Jinan 250012, China;

关键词: Pancreatic adenocarcinoma;    Necroptosis;    Prognosis;    Exosomes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Pancreatic adenocarcinoma (PAAD) has become one of the deadliest malignancies in the world. Since necroptosis plays a crucial role in regulating the immune system, it is necessary to develop novel prognostic biomarkers associated with necroptosis and explore its potential role in PAAD. The transcriptome RNA-seq data of PAAD were downloaded from the TCGA and GTEx databases. A prognostic signature was constructed by the least absolute shrinkage and selection operator (LASSO) Cox regression, and its prognostic value was evaluated by nomogram and validated in an independent GEO cohort. We identified a total of 24 differentially expressed NRGs in PAAD, and constructed a prognostic signature with 5 NRGs, which showed good performance in predicting the prognosis of PAAD patients. The ROC curves for 1-, 3-, and 5-year survival rate were 0.652, 0.778, and 0.817, respectively. This prognostic signature showed consistent prognosis prediction in an independent patient cohort. Furthermore, the correlations between 5-NRGs signature and TMB, MSI, histopathological classification, immune infiltration, immune types, and immunomodulators were all significant. Notably, the expression profiles of the five NRGs in exosomes of serum were consistent with their expression in tumor tissues. These data suggested that the 5-NRGs signature is a promising biomarker for predicting the prognosis of PAAD.

【 授权许可】

Unknown