Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study

AIDS Research and Therapy

Kathryn Manning¹  Nectarios Sophocles Papavarnavas¹  Gary Maartens²  Milah Govender³  Fahd Conrad⁴ 

[1]Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town

[2]Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town

[3]Quality and Safety Unit, Groote Schuur Hospital

[4]Trauma and Emergency Unit, Floor E11A, Management Suite, Groote Schuur Hospital

关键词: Loss to follow-up;    Post exposure prophylaxis;    Health care workers;    HIV;   

DOI  :  10.1186/s12981-017-0149-8

来源: DOAJ

【 摘 要 】

Abstract Background There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used. Methods A retrospective cohort study was conducted of HCWs attending a referral hospital’s Occupational Health Clinic in Cape Town, South Africa for post-exposure prophylaxis (PEP) during a period when tenofovir was available. Our primary outcome was LTFU at the 3-month visit. We selected seven variables a priori for our logistic regression model and ensured there were at least 10 outcome events per variable to minimize bias. Results Two hundred and ninety-three folders were evaluated for descriptive analysis. LTFU worsened with successive visits: 36% at 6 weeks, 60% at 3 months, and 72% at 6 months. In multivariate analysis at the 3-month visit LTFU was associated with age (adjusted odds ratio (aOR), 0.6 per 10-year increase [95% CI, 0.5–0.9]), HCW category of doctor (aOR 2.7 [95% CI, 1.3–5.5]), and time from exposure to receiving PEP of more than 24 h (aOR 5.9 [95% CI, 1.3–26.9]). Conclusion We identified factors associated with LTFU of HCWs after occupational HIV exposure, which could be used to target interventions to improve follow-up.

【 授权许可】

Unknown