Optimal Control Strategy on the Transmission Dynamics of Herpes Simplex Virus-II (HSV-II)

Applications of Modelling and Simulation

Boka Kumsa Bole¹  Eshetu Dadi Gurmu¹  Purnachandra Rao Koya¹ 

[1] Department of Mathematics, Wollega University, Nekemte, Ethiopia;

关键词: mathematical model;    numerical solution;    optimal control;    stability;   

DOI  :  

来源: DOAJ

【 摘 要 】

In this paper, optimal control theory is applied to Herpes Simplex Virus-II transmission model given by a system of non-linear ordinary differential equations. Optimal control strategy was employed to study the level of effort needed to control the transmission dynamics of HSV-II diseases using three controls; prevention, screening and treatment control strategies. The necessary conditions for the existence of the optimal controls was established using Pontryagin’s Maximum Principle. Optimal control system was performed with help of Runge-Kutta forward-backward sweep numerical approximation method. Finally, numerical simulations reveal that a combination of prevention, screening and treatment is the most effective strategy to eradicate the disease from the community.

【 授权许可】

Unknown