Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives ‡

Molecules

Zdeněk Wimmer¹  Uladzimir Bildziukevich¹  Zülal Özdemir¹ 

[1] Institute of Experimental Botany of the Czech Academy of Sciences, Isotope Laboratory, Vídeňská 1083, 14220 Prague 4, Czech Republic;

关键词: betulinic acid;    structural modification;    supramolecular self-assembly;    cytotoxicity;    antitumor activity;    antiviral activity;    physicochemical parameters;    adme parameters;   

DOI  :  10.3390/molecules24193546

来源: DOAJ

【 摘 要 】

The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015−2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data.

【 授权许可】

Unknown