How Glucocorticoids Affect the Neutrophil Life

International Journal of Molecular Sciences

Simona Ronchetti¹  Erika Ricci¹  Carlo Riccardi¹  Graziella Migliorati¹  Marco Gentili¹ 

[1] Department of Medicine, Section of Pharmacology, University of Perugia, 06129 Perugia, Italy;

关键词: glucocorticoids;    neutrophils;    inflammation;    innate immunity;   

DOI  :  10.3390/ijms19124090

来源: DOAJ

【 摘 要 】

Glucocorticoids are hormones that regulate several functions in living organisms and synthetic glucocorticoids are the most powerful anti-inflammatory pharmacological tool that is currently available. Although glucocorticoids have an immunosuppressive effect on immune cells, they exert multiple and sometimes contradictory effects on neutrophils. From being extremely sensitive to the anti-inflammatory effects of glucocorticoids to resisting glucocorticoid-induced apoptosis, neutrophils are proving to be more complex than they were earlier thought to be. The aim of this review is to explain these complex pathways by which neutrophils respond to endogenous or to exogenous glucocorticoids, both under physiological and pathological conditions.

【 授权许可】

Unknown