Intracrine Endorphinergic Systems in Modulation of Myocardial Differentiation

International Journal of Molecular Sciences

Margherita Maioli¹  Carlo Ventura²  Federica Facchin²  Chiara Zannini²  Eva Bianconi²  Silvia Canaider²  Riccardo Tassinari²  Elena Olivi²  Claudia Cavallini²  Valentina Taglioli² 

[1] Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy;National Laboratory of Molecular Biology and Stem Cell Bioengineering - Eldor Lab, National Institute of Biostructures and Biosystems (NIBB), at the Innovation Accelerator, CNR, Via Piero Gobetti 101, 40129 Bologna, Italy;

关键词: stem cells;    dynorphin b;    prodynorphin gene;    intracrine;    nuclear opioid receptors;    transcription factors;    cardiogenesis;    cardiac regeneration;    hyaluronan esters;    electromagnetic fields;   

DOI  :  10.3390/ijms20205175

来源: DOAJ

【 摘 要 】

A wide variety of peptides not only interact with the cell surface, but govern complex signaling from inside the cell. This has been referred to as an “intracrine” action, and the orchestrating molecules as “intracrines”. Here, we review the intracrine action of dynorphin B, a bioactive end-product of the prodynorphin gene, on nuclear opioid receptors and nuclear protein kinase C signaling to stimulate the transcription of a gene program of cardiogenesis. The ability of intracrine dynorphin B to prime the transcription of its own coding gene in isolated nuclei is discussed as a feed-forward loop of gene expression amplification and synchronization. We describe the role of hyaluronan mixed esters of butyric and retinoic acids as synthetic intracrines, controlling prodynorphin gene expression, cardiogenesis, and cardiac repair. We also discuss the increase in prodynorphin gene transcription and intracellular dynorphin B afforded by electromagnetic fields in stem cells, as a mechanism of cardiogenic signaling and enhancement in the yield of stem cell-derived cardiomyocytes. We underline the possibility of using the diffusive features of physical energies to modulate intracrinergic systems without the needs of viral vector-mediated gene transfer technologies, and prompt the exploration of this hypothesis in the near future.

【 授权许可】

Unknown