Links between Inflammation and Postoperative Cancer Recurrence

Journal of Clinical Medicine

Tomonari Kinoshita¹  Taichiro Goto² 

[1] Division of Thoracic Surgery, Japanese Red Cross Ashikaga Hospital, Tochigi 326-0843, Japan;Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, Yamanashi 400-8506, Japan;

关键词: cancer;    cancer recurrence;    clinical index;    inflammation;    postoperative recurrence;    resection;   

DOI  :  10.3390/jcm10020228

来源: DOAJ

【 摘 要 】

Despite complete resection, cancer recurrence frequently occurs in clinical practice. This indicates that cancer cells had already metastasized from their organ of origin at the time of resection or had circulated throughout the body via the lymphatic and vascular systems. To obtain this potential for metastasis, cancer cells must undergo essential and intrinsic processes that are supported by the tumor microenvironment. Cancer-associated inflammation may be engaged in cancer development, progression, and metastasis. Despite numerous reports detailing the interplays between cancer and its microenvironment via the inflammatory network, the status of cancer-associated inflammation remains difficult to recognize in clinical settings. In the current paper, we reviewed clinical reports on the relevance between inflammation and cancer recurrence after surgical resection, focusing on inflammatory indicators and cancer recurrence predictors according to cancer type and clinical indicators.

【 授权许可】

Unknown