Disrupted anatomic networks in the 22q11.2 deletion syndrome

NeuroImage: Clinical

Kosha Ruparel, MS¹  J. Eric Schmitt, MD PhD¹  Amy Cassidy, MS¹  Monica E. Calkins, PhD¹  Ruben C. Gur, PhD¹  David R. Roalf, PhD¹  Raquel E. Gur, MD PhD¹  James Yi, MD PhD¹  Theodore D. Satterthwaite, MD MA¹  Margaret C. Souders, PhD CRNP²  Elaine H. Zackai, MD²  Donna M. McDonald-McGinn, MS CGC²  Beverly S. Emanuel, PhD² 

[1] Brain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA;Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA;

关键词: 22q11DS;    cortical thickness;    morphometry;    network;    MRI;    schizophrenia;   

DOI  :  10.1016/j.nicl.2016.08.020

来源: DOAJ

【 摘 要 】

The 22q11.2 deletion syndrome (22q11DS) is an uncommon genetic disorder with an increased risk of psychosis. Although the neural substrates of psychosis and schizophrenia are not well understood, aberrations in cortical networks represent intriguing potential mechanisms. Investigations of anatomic networks within 22q11DS are sparse. We investigated group differences in anatomic network structure in 48 individuals with 22q11DS and 370 typically developing controls by analyzing covariance patterns in cortical thickness among 68 regions of interest using graph theoretical models. Subjects with 22q11DS had less robust geographic organization relative to the control group, particularly in the occipital and parietal lobes. Multiple global graph theoretical statistics were decreased in 22q11DS. These results are consistent with prior studies demonstrating decreased connectivity in 22q11DS using other neuroimaging methodologies.

【 授权许可】

Unknown