Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo

Antibodies

Daniel Hawiger¹  Jessica Bourque¹ 

[1] Doisy Research Center, Department of Molecular Microbiology and Immunology, School of Medicine, Saint Louis University, 1100 S. Grand Blvd., St. Louis, MO 63104, USA;

关键词: dendritic cells;    antigen targeting;    antigen delivery;    chimeric antibodies;    autoimmunity;    immunity;   

DOI  :  10.3390/antib11010008

来源: DOAJ

【 摘 要 】

Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools for the investigation of the corresponding T cell responses. These approaches originated with the development of the recombinant chimeric antibody against a multilectin receptor, DEC-205, which is present on subsets of murine and human conventional dendritic cells. Following the widespread application of antigen targeting through DEC-205, similar approaches then utilized other epitopes as entry points for antigens delivered by specific antibodies to multiple types of dendritic cells. Overall, these antigen-delivery methodologies helped to reveal the mechanisms underlying tolerogenic and immunogenic T cell responses orchestrated by dendritic cells. Here, we discuss the relevant experimental strategies as well as their future perspectives, including their translational relevance.

【 授权许可】

Unknown