期刊论文详细信息
Molecules | |
Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics | |
MariaDe Fenza1  Anna Esposito1  Daniele D’Alonzo1  Annalisa Guaragna2  | |
[1] Department of Chemical Sciences, University of Naples Federico II, Via Cintia, 80126 Naples, Italy;Department of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale V. Tecchio 80, 80125 Naples, Italy; | |
关键词: immucillins; nucleoside analogues; de novo synthesis; iminosugars; biomimetics; conformationally restricted nucleosides; | |
DOI : 10.3390/molecules26061652 | |
来源: DOAJ |
【 摘 要 】
The de novo synthesis of piperidine nucleosides from our homologating agent 5,6-dihydro-1,4-dithiin is herein reported. The structure and conformation of nucleosides were conceived to faithfully resemble the well-known nucleoside drugs Immucillins H and A in their bioactive conformation. NMR analysis of the synthesized compounds confirmed that they adopt an iminosugar conformation bearing the nucleobases and the hydroxyl groups in the appropriate orientation.
【 授权许可】
Unknown