Peripheral and central mechanisms of stress resilience

Neurobiology of Stress

Madeline L. Pfau¹  Scott J. Russo¹ 

[1] Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA;

关键词: Resilience;    Stress;    Depression;    Anxiety;    Neuroimmune;    Plasticity;   

DOI  :  10.1016/j.ynstr.2014.09.004

来源: DOAJ

【 摘 要 】

Viable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology and behavior despite exposure to marked psychological stress. This phenomenon, documented in both humans and animal models, involves coordinated biological mechanisms in numerous bodily systems, both peripheral and central. In this review, we provide an overview of resilience mechanisms throughout the body, discussing current research in animal models investigating the roles of the neuroendocrine, immune, and central nervous systems in behavioral resilience to stress.

【 授权许可】

Unknown