Near-Infrared-II Bioimaging for in Vivo Quantitative Analysis

Frontiers in Chemistry

Sha Yang¹  Qinglai Yang²  Li Tang²  Xiaofeng Tan² 

[1] Department of Pathology and Tumor Pathology Research Group, Xiangnan University, Chenzhou, China;The First Affiliated Hospital and Center for Molecular Imaging Probe, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, China;

关键词: NIR-II bioimaging;    In vivo quantitative analysis;    ratiometric;    fluorescence;    photoacoustic;    lifetime;   

DOI  :  10.3389/fchem.2021.763495

来源: DOAJ

【 摘 要 】

Near-Infrared-II (NIR-II) bioimaging is a newly emerging visualization modality in real-time investigations of biological processes research. Owning to advances in reducing photon scattering and low tissue autofluorescence levels in NIR-II region (1,000–1700 nm), NIR-II bioimaging affords high resolution with increasing tissue penetration depth, and it shows greater application potential for in vivo detection to obtain more detailed qualitative and quantitative parameters. Herein, this review summarizes recent progresses made on NIR-II bioimaging for quantitative analysis. These emergences of various NIR-II fluorescence, photoacoustic (PA), luminescence lifetime imaging probes and their quantitative analysis applications are comprehensively discussed, and perspectives on potential challenges facing in this direction are also raised.

【 授权许可】

Unknown