BMC Genetics | |
Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter | |
关键词: MnSOD; Human manganese superoxide dismutase; genotyping; | |
DOI : 10.1186/1471-2156-5-33 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species constituting a major cellular defense mechanism against agents that induce oxidative stress. The
Results
A new TaqMan allelic discrimination genotype method was successfully applied to genomic DNA samples derived from blood, buccal swabs, snap frozen tissue and paraffin blocks. The polymorphism was shown to be in Hardy-Weinberg Equilibrium in an evaluation of 130 Caucasians from Warsaw, Poland: 44 (33.8%) were heterozygous and 6 (4.6%) were homozygous for -102T.
Conclusion
This report represents the first description of the
【 授权许可】
Unknown