The Rational Design and Biological Mechanisms of Nanoradiosensitizers

Nanomaterials

Xiaoling Wang¹  Hainan Sun¹  Shumei Zhai¹ 

[1] Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong, China;

关键词: nanoradiosensitizers;    radiosensitization;    radiotherapy;    biological mechanisms;    physicochemical properties;   

DOI  :  10.3390/nano10030504

来源: DOAJ

【 摘 要 】

Radiotherapy (RT) has been widely used for cancer treatment. However, the intrinsic drawbacks of RT, such as radiotoxicity in normal tissues and tumor radioresistance, promoted the development of radiosensitizers. To date, various kinds of nanoparticles have been found to act as radiosensitizers in cancer radiotherapy. This review focuses on the current state of nanoradiosensitizers, especially the related biological mechanisms, and the key design strategies for generating nanoradiosensitizers. The regulation of oxidative stress, DNA damage, the cell cycle, autophagy and apoptosis by nanoradiosensitizers in vitro and in vivo is highlighted, which may guide the rational design of therapeutics for tumor radiosensitization.

【 授权许可】

Unknown