期刊论文详细信息
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
p53‐Dependent Mitochondrial Compensation in Heart Failure With Preserved Ejection Fraction
Xiaonan Chen1  Hao Lin1  Huili Zhang1  Alex Chia Yu Chang1  Jianan Pan1  Shuying Huang1  Weiyao Xiong2  Shan Xu2  Shufang He2  Ming Lei2 
[1] Department of Cardiology Ninth People’s HospitalShanghai Jiao Tong University School of Medicine Shanghai China;Shanghai Institute of Precision MedicineNinth People’s HospitalShanghai Jiao Tong University School of Medicine Shanghai China;
关键词: aging;    HFpEF;    mitochondrial homeostasis;    p53 activation;   
DOI  :  10.1161/JAHA.121.024582
来源: DOAJ
【 摘 要 】

Background Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of patients with heart failure. Clinically, HFpEF prevalence shows age and gender biases. Although the majority of patients with HFpEF are elderly, there is an emergence of young patients with HFpEF. A better understanding of the underlying pathogenic mechanism is urgently needed. Here, we aimed to determine the role of aging in the pathogenesis of HFpEF. Methods and Results HFpEF dietary regimen (high‐fat diet + Nω‐Nitro‐L‐arginine methyl ester hydrochloride) was used to induce HFpEF in wild type and telomerase RNA knockout mice (second‐generation and third‐generation telomerase RNA component knockout), an aging murine model. First, both male and female animals develop HFpEF equally. Second, cardiac wall thickening preceded diastolic dysfunction in all HFpEF animals. Third, accelerated HFpEF onset was observed in second‐generation telomerase RNA component knockout (at 6 weeks) and third‐generation telomerase RNA component knockout (at 4 weeks) compared with wild type (8 weeks). Fourth, we demonstrate that mitochondrial respiration transitioned from compensatory state (normal basal yet loss of maximal respiratory capacity) to dysfunction (loss of both basal and maximal respiratory capacity) in a p53 dosage dependent manner. Last, using myocardial‐specific p53 knockout animals, we demonstrate that loss of p53 activation delays the development of HFpEF. Conclusions Here we demonstrate that p53 activation plays a role in the pathogenesis of HFpEF. We show that short telomere animals exhibit a basal level of p53 activation, mitochondria upregulate mtDNA encoded genes as a mean to compensate for blocked mitochondrial biogenesis, and loss of myocardial p53 delays HFpEF onset in high fat diet + Nω‐Nitro‐L‐arginine methyl ester hydrochloride challenged murine model.

【 授权许可】

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