Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes

Cells

Masateru Taniguchi¹  Masamitsu Konno²  Takahiro Arai²  Takaaki Hirotsu²  Masatoshi Kitakaze²  Toru Kitagawa²  Ken Ofusa²  Ayumu Asai²  Hideshi Ishii²  Hidetoshi Eguchi²  Yuichiro Doki²  Yu Takeda²  Masami Yabumoto²  Andrea Vecchione³  Daisaku Yamada⁴  Shogo Kobayashi⁴  Hirofumi Akita⁴ 

[1] Artificial Intelligence Research Center, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan;Center of Medical Innovation and Translational Research (CoMIT), Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japan;Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, Santo Andrea Hospital, via di Grottarossa, 1035-00189 Rome, Italy;Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

关键词: exosome;    cancer;    immunology;    surgery;   

DOI  :  10.3390/cells9071645

来源: DOAJ

【 摘 要 】

Exosomes (EXs), a type of extracellular vesicles secreted from various cells and especially cancer cells, mesenchymal cells, macrophages and other cells in the tumor microenvironment (TME), are involved in biologically malignant behaviors of cancers. Recent studies have revealed that EXs contain microRNAs on their inside and express proteins and glycolipids on their outsides, every component of which plays a role in the transmission of genetic and/or epigenetic information in cell-to-cell communications. It is also known that miRNAs are involved in the signal transduction. Thus, EXs may be useful for monitoring the TME of tumor tissues and the invasion and metastasis, processes that are associated with patient survival. Because several solid tumors secrete immune checkpoint proteins, including programmed cell death-ligand 1, the EX-mediated mechanisms are suggested to be potent targets for monitoring patients. Therefore, a companion therapeutic approach against cancer metastasis to distant organs is proposed when surgical removal of the primary tumor is performed. However, EXs and immune checkpoint mechanisms in pancreatic cancer are not fully understood, we provide an update on the recent advances in this field and evidence that EXs will be useful for maximizing patient benefit in precision medicine.

【 授权许可】

Unknown