Biogenic nanosized gold particles: Physico-chemical characterization and its anticancer response against breast cancer

Biotechnology Reports

Monoj Kumar Das¹  Aftab Ansari²  Dambarudhar Mohanta²  Neelu Singh³  Paulraj Rajamani³ 

[1] Cancer Genetics and Chemoprevention Research Group, Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, Tezpur, 784028, Assam, India;Nanoscience and Soft Matter Laboratory, Department of Physics, Tezpur University, Napaam, Tezpur, 784028, Assam, India;School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 10067, India;

关键词: Biosynthesized;    Gold nanoparticles;    Anticancer;    Antiproliferation;   

DOI  :  

来源: DOAJ

【 摘 要 】

With the advancement of nanotechnology, the nano-sized particles make an imprint on our daily lives.The present investigation revealed that biomolecules present in seed exudates of Vigna radiata are responsible for the synthesis of AuNPs, confirmed by the routine characterization techniques. Anticancer efficacy showed by AuNPs might be due to the release of phytochemicals in the exudate which is being adsorbed on the surface of AuNPs referencing their anticancer efficacy against the tested breast cancer cell lines. Inhibition of clonogenicity and cell cycle arrest at G2/M phase then apoptosis of AuNPs was also observed, but found nontoxic to the human PBMC cells which further confirms its biocompatible property Among the various physicochemical study, present AuNPs shows unique information, they show photoluminescent property which may be used for bioimaging purposes. However, further molecular analysis needs to be explored to understand the underlying mechanism for therapeutic and biomedical application.

【 授权许可】

Unknown