The Role of Sonic Hedgehog in Craniofacial Patterning, Morphogenesis and Cranial Neural Crest Survival

Journal of Developmental Biology

Yeliz Boglev¹  Sebastian Dworkin²  Stephen J. Goldie²  Harley Owens² 

[1] Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia;Department of Medicine, Monash University Central Clinical School, Prahran, Victoria 3004, Australia;

关键词: Hedgehog;    neural crest;    craniofacial;    maxilla;    mandible;    development;    cleft palate;   

DOI  :  10.3390/jdb4030024

来源: DOAJ

【 摘 要 】

Craniofacial defects (CFD) are a significant healthcare problem worldwide. Understanding both the morphogenetic movements which underpin normal facial development, as well as the molecular factors which regulate these processes, forms the cornerstone of future diagnostic, and ultimately, preventative therapies. The soluble morphogen Sonic hedgehog (Shh), a vertebrate orthologue of Drosophila hedgehog, is a key signalling factor in the regulation of craniofacial skeleton development in vertebrates, operating within numerous tissue types in the craniofacial primordia to spatiotemporally regulate the formation of the face and jaws. This review will provide an overview of normal craniofacial skeleton development, and focus specifically on the known roles of Shh in regulating the development and progression of the first pharyngeal arch, which in turn gives rise to both the upper jaw (maxilla) and lower jaw (mandible).

【 授权许可】

Unknown