How Diet Intervention via Modulation of DNA Damage Response through MicroRNAs May Have an Effect on Cancer Prevention and Aging, an in Silico Study

International Journal of Molecular Sciences

Dario Coletti¹  Maria C. Albertini²  Luigi Campanella³  Zbigniew Darzynkiewicz⁴  Felicia Carotenuto⁵  Alessandra Vilmercati⁵  Laura Teodori⁵ 

[1] Department of Biological Adaptation and Aging B2A, University Pierre et Marie Curie Paris 06, Paris 75252, France;Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino 61029, Italy;Department of Chemistry, University of Rome “Sapienza”, Rome, 00185, Italy;Department of Pathology, New York Medical College, Valhalla, NY 10595, USA;Diagnostics and Metrology (FSN-TECFIS-DIM), ENEA, C.R. Frascati, Rome 00044, Italy;

关键词: food;    bioactive compounds;    n3-PUFA;    resveratrol;    curcumin;    epi-gallocatechin-3gallate;    chemoprevention;   

DOI  :  10.3390/ijms17050752

来源: DOAJ

【 摘 要 】

The DNA damage response (DDR) is a molecular mechanism that cells have evolved to sense DNA damage (DD) to promote DNA repair, or to lead to apoptosis, or cellular senescence if the damage is too extensive. Recent evidence indicates that microRNAs (miRs) play a critical role in the regulation of DDR. Dietary bioactive compounds through miRs may affect activity of numerous genes. Among the most studied bioactive compounds modulating expression of miRs are epi-gallocatechin-3-gallate, curcumin, resveratrol and n3-polyunsaturated fatty acids. To compare the impact of these dietary compounds on DD/DDR network modulation, we performed a literature search and an in silico analysis by the DIANA-mirPathv3 software. The in silico analysis allowed us to identify pathways shared by different miRs involved in DD/DDR vis-à-vis the specific compounds. The results demonstrate that certain miRs (e.g., -146, -21) play a central role in the interplay among DD/DDR and the bioactive compounds. Furthermore, some specific pathways, such as “fatty acids biosynthesis/metabolism”, “extracellular matrix-receptor interaction” and “signaling regulating the pluripotency of stem cells”, appear to be targeted by most miRs affected by the studied compounds. Since DD/DDR and these pathways are strongly related to aging and carcinogenesis, the present in silico results of our study suggest that monitoring the induction of specific miRs may provide the means to assess the antiaging and chemopreventive properties of particular dietary compounds.

【 授权许可】

Unknown