Intervirology | |
SARS-COV-2 Triggers the Development of Class I and Class II HLA Antibodies in Recovered Convalescent Plasma Donors | |
Rayan Mohammed Bawayan1  Khalid Elhassan1  Ghadeer Albishi1  Ashraf Dada1  Nabeela AlBaz1  Turki Sobahy2  Lama Hefni2  Edward Cupler2  Sawsan Bassi2  Abeer N. Alshukairi3  Basem Alraddadi3  Ghassan Wali3  | |
[1] Department of Pathology and Laboratory Medicine/King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia;Research Center of King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia;Section Infection Diseases, Department of Internal Medicine of King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; | |
关键词: sars-cov-2; covid-19; hla antibodies; immune response; convalescent plasma; | |
DOI : 10.1159/000524016 | |
来源: DOAJ |
【 摘 要 】
Various studies have shown that SARS-CoV-2 is a highly immunogenic virus. It is known that different types of immunogenic viral pathogens could trigger the formation of HLA antibodies. Therefore, there is a concern that the SARS-CoV-2 could also induce the development of HLA antibodies in volunteers, who donate convalescent plasma after their recovery from COVID-19. HLA antibodies have been identified as the main cause for transfusion-related acute lung injury (TRALI), a well-documented life-threatening complication of transfusions. The TRALI risk could be high in COVID-19 patients who need convalescent plasma, as such patients usually have already an impaired respiratory system affected by the SARS-CoV-2 infection. In this study, we screened 34 convalescent plasma donors on the presence of antibodies against HLA class I and II antigens. All included donors have no any history of sensitization events such as blood transfusions, pregnancy, or previous transplants. We found a high rate of HLA antibody formation in convalescent plasma donors. The frequency of positivity for HLA antibodies for class I, class II, class I and II, and the overall reactivity was 23%, 31%, 46%, and 76%, respectively. The presented data suggest a closed correlation between SARS-CoV-2 virus infection and the development of HLA antibodies in recovered convalescent plasma donors. This finding might have the potential to reduce the risk of TRALI and mortality rate in COVID-19 patients by implementing HLA diagnostic strategies before the administration of convalescent plasma.
【 授权许可】
Unknown