Validação de método analítico por cromatografia líquida de alta eficiência para doseamento do adapaleno em suspensões de nanocápsulas

Química Nova

Sandra Cadore Peixoto¹  Flábio R. Pons¹  Marta Palma Alves¹  Gabriela D'Avila Farias¹  Jerusa Goi Barrios¹  Márcia Bruschi¹  Renata Platcheck Raffin¹  Isabel Roggia¹ 

[1] Centro Universitário Franciscano;

关键词: adapalene;    validation;    HPLC;   

DOI  :  10.1590/S0100-40422011000800029

来源: DOAJ

【 摘 要 】

Adapalene is a retinoid drug often used for disorders of the skin, mainly acne. In this work, an analytical method for the quantification of adapaleno in suspensions of nanocapsules by HPLC was developed and validated. The method was linear in the range of 10-30 µg mL-1, with a good correlation coefficient (r = 0.994). Precision and accuracy analysis showed low relative standard deviation (< 4.6%) and a good recovery percentual (98.2-106.9%). The procedure was specific, linear, precise, exact and robust so that the method can be applied in quantification of adapalene in suspensions of nanocapsules.

【 授权许可】

Unknown