PHF6 Degrees of Separation: The Multifaceted Roles of a Chromatin Adaptor Protein

Genes

David J. Picketts¹  Matthew A.M. Todd¹  Danton Ivanochko¹ 

[1] Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8L6, Canada;

关键词: AML;    BFLS;    hematopoiesis;    neurogenesis;    nucleolus;    NuRD;    PAF1;    PHF6;    T-ALL;    XLID;   

DOI  :  10.3390/genes6020325

来源: DOAJ

【 摘 要 】

The importance of chromatin regulation to human disease is highlighted by the growing number of mutations identified in genes encoding chromatin remodeling proteins. While such mutations were first identified in severe developmental disorders, or in specific cancers, several genes have been implicated in both, including the plant homeodomain finger protein 6 (PHF6) gene. Indeed, germline mutations in PHF6 are the cause ofthe Börjeson–Forssman–Lehmann X-linked intellectual disability syndrome (BFLS),while somatic PHF6 mutations have been identified in T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). Studies from different groups over the last few years have made a significant impact towards a functional understanding of PHF6 protein function. In this review, we summarize the current knowledge of PHF6 with particular emphasis on how it interfaces with a distinct set of interacting partners and its functional roles in the nucleoplasm and nucleolus. Overall, PHF6 is emerging as a key chromatin adaptor protein critical to the regulation of neurogenesis and hematopoiesis.

【 授权许可】

Unknown