Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats

International Journal of Molecular Sciences

Chao-Yuan Chang¹  Kung-Yen Chen¹  Chun-Jen Huang¹  Hung-Jen Shih²  I-Tao Huang³  Pei-Shan Tsai⁴ 

[1] Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan;Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan;Medical Education Unit, Redcliffe Hospital, Metro North Hospital and Health Service, Queensland Government, Redcliffe, QLD 4020, Australia;School of Nursing, College of Nursing, Taipei Medical University, Taipei 110, Taiwan;

关键词: right heart failure;    oxidation;    mitochondria;    inflammation;    inflammasomes;    apoptosis;   

DOI  :  10.3390/ijms20184622

来源: DOAJ

【 摘 要 】

We investigated whether magnesium sulfate (MgSO₄) mitigated pulmonary hypertension progression in rats. Pulmonary hypertension was induced by a single intraperitoneal injection of monocrotaline (60 mg/kg). MgSO₄ (100 mg/kg) was intraperitoneally administered daily for 3 weeks, from the seventh day after monocrotaline injection. Adult male rats were randomized into monocrotaline (MCT) or monocrotaline plus MgSO₄ (MM) groups (n = 15 per group); control groups were maintained simultaneously. For analysis, surviving rats were euthanized on the 28^th day after receiving monocrotaline. The survival rate was higher in the MM group than in the MCT group (100% versus 73.3%, p = 0.043). Levels of pulmonary artery wall thickening, α-smooth muscle actin upregulation, right ventricular systolic pressure increase, and right ventricular hypertrophy were lower in the MM group than in the MCT group (all p < 0.05). Levels of lipid peroxidation, mitochondrial injury, inflammasomes and cytokine upregulation, and apoptosis in the lungs and right ventricle were lower in the MM group than in the MCT group (all p < 0.05). Notably, the mitigation effects of MgSO₄ on pulmonary artery wall thickening and right ventricular hypertrophy were counteracted by exogenous calcium chloride. In conclusion, MgSO₄ mitigates pulmonary hypertension progression, possibly by antagonizing calcium.

【 授权许可】

Unknown