The Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis

Frontiers in Psychology

Andrew Knight¹  Filipa Peste²  Tiago A. Marques³  Constança Carvalho⁴  Luís M. Vicente⁴ 

[1] Centre for Animal Welfare, University of Winchester, Winchester, United Kingdom;Centre for Environmental and Marine Studies, Departamento de Biologia, Universidade de Aveiro, Aveiro, Portugal;Centre for Research into Ecological and Environmental Modelling, Departamento de Biologia Animal, Centro de Estatística e Aplicações, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal;Centro de Filosofia das Ciências da Universidade de Lisboa (CFCUL), Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal;

关键词: major depressive disorder;    animal models;    animal use alternatives;    citation analysis;    rat;   

DOI  :  10.3389/fpsyg.2020.01486

来源: DOAJ

【 摘 要 】

Major depressive disorder (MDD) is the most severe depression type and one of the leading causes of morbidity worldwide. Animal models are widely used to understand MDD etiology, pathogenesis, and treatment, but the efficacy of this research for patients has barely been systematically evaluated. Such evaluation is important given the resource consumption and ethical concerns incurred by animal use. We used the citation tracking facilities within Web of Science and Scopus to locate citations of original research papers on rats related to MDD published prior to 2013—to allow adequate time for citations—identified in PubMed and Scopus by relevant search terms. Resulting citations were thematically coded in eight categories, and descriptive statistics were calculated. 178 publications describing relevant rat studies were identified. They were cited 8,712 times. More than half (4,633) of their citations were by other animal studies. 794 (less than 10%) were by human medical papers. Citation analysis indicates that rat model research has contributed very little to the contemporary clinical understanding of MDD. This suggests a misuse of limited funding hence supporting a change in allocation of research and development funds targeting this disorder to maximise benefits for patients.

【 授权许可】

Unknown