Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases

International Journal of Molecular Sciences

Paula Aparicio¹  Rosario Osta¹  Raquel Manzano¹  Miriam de la Torre¹  Laura Moreno-Martínez¹  Leticia Moreno-García¹  Tresa López-Royo¹  Nora Molina¹  JanneMarkus Toivonen¹  AnaCristina Calvo¹  Pilar Zaragoza¹ 

[1] Department of Anatomy, Embryology and Animal Genetics, University of Zaragoza, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Agroalimentary Institute of Aragon (IA2), Institute of Health Research of Aragon (IIS), Calle Miguel Servet 13, 50013 Zaragoza, Spain;

关键词: competing endogenous RNAs (ceRNA);    neurodegenerative diseases (NDDs);    extracellular/circulating biomarkers;    microRNA;    long non-coding RNA;    circular RNA;   

DOI  :  10.3390/ijms21249582

来源: DOAJ

【 摘 要 】

Protein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcriptome and are particularly abundant in the central nervous system, where they have been proposed to be involved in the onset and development of NDDs. Interestingly, some ncRNAs (such as lncRNAs, circRNAs and pseudogenes) share a common functionality in their ability to regulate gene expression by modulating miRNAs in a phenomenon known as the competing endogenous RNA mechanism. Moreover, ncRNAs are found in body fluids where their presence and concentration could serve as potential non-invasive biomarkers of NDDs. In this review, we summarize the ceRNA networks described in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis and spinocerebellar ataxia type 7, and discuss their potential as biomarkers of these NDDs. Although numerous studies have been carried out, further research is needed to validate these complex interactions between RNAs and the alterations in RNA editing that could provide specific ceRNET profiles for neurodegenerative disorders, paving the way to a better understanding of these diseases.

【 授权许可】

Unknown