Ovarian cancer subtypes and survival in relation to three comprehensive imaging parameters

Journal of Ovarian Research

Anna Kahn¹  Hanna Sartor¹  Päivi Kannisto²  Mihaela Asp²  Maria Bjurberg³  Jenny Brändstedt³  Karin Jirström³ 

[1] Diagnostic Radiology, Department of Translational Medicine, Lund University, Skåne University Hospital;Obstetrics and Gynecology, Department of Clinical Sciences, Lund University;Oncology and Pathology, Department of Clinical Sciences, Lund University;

关键词: Ovarian Cancer;    Peritoneal Carcinomatosis;    Lymph nodes;    Breast density;    Survival analyses;   

DOI  :  10.1186/s13048-020-00625-8

来源: DOAJ

【 摘 要 】

Abstract Background Ovarian cancer (OC) is usually detected in late clinical stages, and imaging at diagnosis is crucial. Peritoneal carcinomatosis (PC) and cardio phrenic lymph nodes (CPLN) are pathological findings of computed tomography (CT) and are relevant for surgical planning. Furthermore, mammographic breast density (BD) has shown an association with OC risk and might be prognostically relevant. However, it is not known if PC, CPLN, and BD are associated with aggressive OC subtypes and impaired OC survival. Herein, we investigated associations between three comprehensive image parameters and OC subtypes and survival. Methods The Malmö Diet and Cancer Study is a prospective study that included 17,035 women (1991–1996). Tumor information on 159 OC and information on OC specific survival (last follow-up, 2017-12-31) was registered. The CT and mammography closest to diagnosis were evaluated (Peritoneal Carcinomatosis Index PCI, CPLN, and BD). Associations between CT-PCI, CPLN, and BD vs. clinical stage [stage I vs. advanced stage (II-IV), histological type/grade (high grade serous and endometrioid vs. other subtypes], and OC-specific survival were analyzed by logistic and Cox regression. Results There was a significant association between higher CT-PCI score and advanced clinical stage (adjusted OR 1.26 (1.07–1.49)), adjusted for age at diagnosis and histological type/grade. Increasing CT-PCI was significantly associated with impaired OC specific survival (adjusted HR 1.04 (1.01–1.07)), adjusted for age at diagnosis, histological type/grade, and clinical stage. There was no significant association between PCI and histological type/grade, nor between BD or CPLN vs. the studied outcomes. Conclusions Image PCI score was significantly associated with advanced clinical stages and impaired OC survival. An objective approach (based on imaging) to scoring peritoneal carcinomatosis in ovarian cancer could help surgeons and oncologists to optimize surgical planning, treatment, and care.

【 授权许可】

Unknown