Amnestic Mild Cognitive Impairment and Early Alzheimer’s Disease in an Asian Memory Clinic – Evidence for a Clinical Spectrum

Dementia and Geriatric Cognitive Disorders Extra

关键词: Mild cognitive impairment;    Clinical dementia rating;    Disease spectrum;    Alzheimerߣ;    s disease;   

DOI  :  10.1159/000327519

来源: DOAJ

【 摘 要 】

Objectives: To determine if mild cognitive impairment (MCI) represents a continuum of cognitive and functional deficits. Methods: Clinical data of 164 subjects with no dementia (ND, n = 52), uncertain dementia (n = 69), and mild probable Alzheimer’s disease (AD, n = 43) were reviewed. Uncertain dementia patients were classified as pre-MCI (n = 11), early amnestic MCI (e-aMCI, n = 15) and late amnestic MCI (l-aMCI, n = 15). Cognitive assessments [Chinese Mini-Mental State Examination (CMMSE) and a validated neuropsychological battery], functional assessments (Lawton’s scale for instrumental activities of daily living) and neuroimaging (ischemic lesions and medial temporal lobe atrophy) were reviewed. Results: ND, aMCI and mild AD subjects demonstrated a significant trend for worsening performance for all cognitive and functional measures (ANOVA, p Conclusions: Clinical delineation of aMCI allows the differentiation of those likely to progress for better correlation to biomarker development.

【 授权许可】

Unknown