Bone Invasive Meningioma: Recent Advances and Therapeutic Perspectives

Frontiers in Oncology

Hajime Takase²  Tetsuya Yamamoto² 

[1] Center for Novel and Exploratory Clinical Trials (Y-NEXT), Yokohama City University Hospital, Yokohama, Japan;Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan;

关键词: meningioma;    bone invasion;    recurrence;    translational study;    long-term;   

DOI  :  10.3389/fonc.2022.895374

来源: DOAJ

【 摘 要 】

Meningioma is the most common primary neoplasm of the central nervous system (CNS). Generally, these tumors are benign and have a good prognosis. However, treatment can be challenging in cases with aggressive variants and poor prognoses. Among various prognostic factors that have been clinically investigated, bone invasion remains controversial owing to a limited number of assessments. Recent study reported that bone invasion was not associated with WHO grades, progression, or recurrence. Whereas, patients with longer-recurrence tended to have a higher incidence of bone invasion. Furthermore, bone invasion may be a primary preoperative predictor of the extent of surgical resection. Increasing such evidence highlights the potential of translational studies to understand bone invasion as a prognostic factor of meningiomas. Therefore, this mini-review summarizes recent advances in pathophysiology and diagnostic modalities and discusses future research directions and therapeutic strategies for meningiomas with bone invasion.

【 授权许可】

Unknown