Circular RNAs in Intervertebral Disc Degeneration: An Updated Review

Frontiers in Molecular Biosciences

Matthew T. V. Chan¹  Xuexiao Ma²  Derong Xu²  Chong Sun²  Jialuo Han²  Chuanli Zhou²  Sunny Hei Wong³  William K. K. Wu⁴ 

[1] Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, China;Department of Spine Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore;State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China;

关键词: CircRNAs;    lower back pain;    ncRNAs;    intervertebral disc degeneration;    CircITCH;   

DOI  :  10.3389/fmolb.2021.781424

来源: DOAJ

【 摘 要 】

Low back pain, a common medical condition, could result in severe disability and inflict huge economical and public health burden. Its pathogenesis is attributed to multiple etiological factors, including intervertebral disc degeneration (IDD). Emerging evidence suggests that circular RNAs (circRNAs), a major type of regulatory non-coding RNA, play critical roles in cellular processes that are pertinent to IDD development, including nucleus pulposus cell proliferation and apoptosis as well as extracellular matrix deposition. Increasing number of translational studies also indicated that circRNAs could serve as novel biomarkers for the diagnosis of IDD and/or predicting its clinical outcomes. Our review aims to discuss the recent progress in the functions and mechanisms of newly discovered IDD-related circRNAs.

【 授权许可】

Unknown