IMMUNOLOGICAL ASPECTS OF ENDOMETRIAL DISEASE

Alʹmanah Kliničeskoj Mediciny

T. N. Manannikova¹  T. Z. Chanturia¹  O. V. Machanskite¹  A. A. Popov¹  T. S. Budykina¹  B. A. Slobodyanyuk¹  A. A. Fedorov¹ 

[1] Moscow Regional Scientific Research Institute for Obstetrics and Gynecology;

关键词: endometriosis;    chemokine;    peritoneal fluid;    peripheral blood;    macrophages;    monocytes;   

DOI  :  10.18786/2072-0505-2015-37-123-128

来源: DOAJ

【 摘 要 】

Background: Immunological processes involving peritoneal macrophages could play a critical role in pathophysiology of external genital endometriosis.Aim: To assess levels of MCP-1, RANTES, and C-reactive protein and to identify their correlations with endometriosis.Materials and methods: Seventy two patients were evaluated: 26 healthy controls and 46 with endometriosis. Patients were divided into groups as follows: 17 with superficial endometriosis, 18 with endometriomas and 11 with deep infiltrative endometriosis. All patients underwent a laparoscopy during the proliferative phase of the cycle; levels of peritoneal and serum MCP-1, RANTES and C-reactive protein were measured using standard ELISA assays.Results: There were positive correlations between serum MCP-1 (p = 0.03) and C-reactive protein(p = 0.045) and severity of endometriosis, that could indicate malfunctioning of peritoneal macrophages in advanced stages of endometriosis. Conclusion: MCP-1 and C-reactive protein levels in peripheral blood can be used as markers of endometriosis activity.

【 授权许可】

Unknown