Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review

Cancers

Pieter B. A. A. van Driel¹  Michiel A. J.van de Sande²  Sarah E. Bosma²  Zeger Rijs²  A. Naweed Shifai²  Stijn Keereweer³  Judith V. M. G. Bovée⁴  Alexander L. Vahrmeijer⁵  Peter J. K. Kuppen⁵  Cornelis F. M. Sier⁵ 

[1] Department of Orthopedic Surgery, Isala Hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands;Department of Orthopedic Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;Department of Otorhinolaryngology Head and Neck Surgery, Erasmus Medical Center Cancer institute, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands;Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;

关键词: TEM1;    VEGFR-1;    EGFR;    VEGFR-2;    IGF-1R;    PDGFRα;   

DOI  :  10.3390/cancers13030557

来源: DOAJ

【 摘 要 】

Surgery is the mainstay of treatment for localized soft tissue sarcomas (STS). The curative treatment highly depends on complete tumor resection, as positive margins are associated with local recurrence (LR) and prognosis. However, determining the tumor margin during surgery is challenging. Real-time tumor-specific imaging can facilitate complete resection by visualizing tumor tissue during surgery. Unfortunately, STS specific tracers are presently not clinically available. In this review, STS-associated cell surface-expressed biomarkers, which are currently already clinically targeted with monoclonal antibodies for therapeutic purposes, are evaluated for their use in near-infrared fluorescence (NIRF) imaging of STS. Clinically targeted biomarkers in STS were extracted from clinical trial registers and a PubMed search was performed. Data on biomarker characteristics, sample size, percentage of biomarker-positive STS samples, pattern of biomarker expression, biomarker internalization features, and previous applications of the biomarker in imaging were extracted. The biomarkers were ranked utilizing a previously described scoring system. Eleven cell surface-expressed biomarkers were identified from which 7 were selected as potential biomarkers for NIRF imaging: TEM1, VEGFR-1, EGFR, VEGFR-2, IGF-1R, PDGFRα, and CD40. Promising biomarkers in common and aggressive STS subtypes are TEM1 for myxofibrosarcoma, TEM1, and PDGFRα for undifferentiated soft tissue sarcoma and EGFR for synovial sarcoma.

【 授权许可】

Unknown