BMC Medical Genetics | |
Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves’ disease and Graves’ ophthalmopathy | |
关键词: Graves’ disease; Graves’ ophthalmopathy; Thymic stromal lymphopoietin; Th17; | |
DOI : 10.1186/1471-2350-13-116 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
Graves disease (GD) is an organ-specific autoimmune disease characterized by hyperthyroidism, diffuse goiter, autoantibodies against thyroid-specific antigens, and dermopathy. Studies of GD have demonstrated the importance of the Th2 and Th17 immune responses in mediating disease progression. In the present study, we investigated the role of a Th2 cytokine, thymic stromal lymphopoietin (TSLP), in GD and Th17 differentiation.
Methods
In this study, we genotyped 470 patients with GD at 3 single nucleotide polymorphisms (SNPs) in
Results
Haplotype analysis indicated that patients with the Ht3 (TCC) haplotype have a 3.28-fold higher risk of developing GD (
Conclusions
These results suggest that polymorphisms in
【 授权许可】
Unknown