High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis

International Journal of Molecular Sciences

Sudhakar Jha¹  Yoshiaki Ito¹  NicoleS. L. Yeo-Teh¹ 

[1] Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore;

关键词: HPV;    human papillomavirus;    cervical cancer;    viral oncogenes;    E6;    E7;    viral-induced cancers;   

DOI  :  10.3390/ijms19061706

来源: DOAJ

【 摘 要 】

Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression. The most well-studied cellular targets of the viral oncogenes E6 and E7 are p53 and pRb, respectively. However, recent research has demonstrated the ability of these two viral factors to target many more cellular factors, including proteins which regulate epigenetic marks and splicing changes in the cell. These have the ability to exert a global change, which eventually culminates to uncontrolled proliferation and carcinogenesis.

【 授权许可】

Unknown