Crystal structures of (S)-(+)-5-(3-bromo/chloro-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione

Acta Crystallographica Section E: Crystallographic Communications

Shigeru Ohba¹  Hisashi Sumida²  Kimiyuki Shibuya²  Minoru Koura² 

[1] Research and Education Center for Natural Sciences, Keio University, Hiyoshi 4-1-1, Kohoku-ku, Yokohama 223-8521, Japan;Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd., 2-17-43, Noguchicho, Higashimurayama, Tokyo 189-0022, Japan;

关键词: crystal structure;    hydantoin;    absolute configuration;    hydrogen bonding;   

DOI  :  10.1107/S2056989015023014

来源: DOAJ

【 摘 要 】

In (S)-(+)-5-(3-bromo-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione, C13H15BrN2O3, (I), the hydantoin groups are connected via intermolecular N—H...O hydrogen bonds, forming a terraced sheet structure. In the chloro analogue, (S)-(+)-5-(3-chloro-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione, C13H15ClN2O3, (II), the intermolecular N—H...O hydrogen-bonding network forms a flat sheet. Comparison of the crystal structures reveals that (II) is more loosely packed than (I).

【 授权许可】

Unknown