Evidence for Progressive Cognitive Deficits in Patients With Major Depressive Disorder

Frontiers in Psychiatry

Weihui Li²  Zexuan Li²  Lingjiang Li²  Qiangli Dong²  Bangshan Liu²  Yumeng Ju²  Xiaowen Lu²  Li Zhang²  Jin Liu²  Mei Liao²  Yan Zhang²  Jinrong Sun²  Liang Zhang²  Mi Wang²  Hua Guo³  Futao Zhao³ 

[1] Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China;Hunan Key Laboratory of Psychiatry and Mental Health, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Mental Health Institute of Central South University, Changsha, China;Zhumadian Psychiatric Hospital, Zhumadian, China;

关键词: major depressive disorder;    cognitive deficit;    progression;    recurrent depression;    the number of episodes;    executive function;   

DOI  :  10.3389/fpsyt.2021.627695

来源: DOAJ

【 摘 要 】

Background: Cognitive deficits have shown progressive feature in major depressive disorder (MDD). However, it remains unknown which component of cognitive function is progressively impaired across episodes of MDD. Here we aim to identify the progressively impaired cognitive components in patients with MDD.Methods: A comprehensive neurocognitive test battery was used to assess the cognitive components (executive function, attention, processing speed, memory, working memory, inhibition, shifting, and verbal fluency) in 35 patients with first-episode MDD (FED), 60 patients with recurrent MDD (RD) and 111 matched healthy controls (HCs). After 6 months of treatment with antidepressant, 20 FED and 36 RD patients achieved clinical remission and completed their second-time neurocognitive tests. Statistical analyses were conducted to identify the impaired cognitive components in the FED and RD groups before and after treatment, and to assess the relationship between the cognitive components and the number of episodes and total illness duration in the MDD patient group.Results: At baseline, both the FED and RD groups showed impairments in all of the cognitive components; the FED and RD groups showed no significant difference in all of the components except for shifting. After remission, only shifting in the RD group showed no significant improvement and remained in an impaired status. Furthermore, shifting was the only component negatively correlated with the number of episodes as well as the total illness duration.Conclusions: Shifting may serve as the progressive cognitive deficit across episodes of MDD.Clinical Trials Registration: Registry name: HPA function and MRI study of trauma-related depression; Registration number: ChiCTR1800014591; URL: http://www.chictr.org.cn/edit.aspx?pid=24669&htm=4.

【 授权许可】

Unknown