Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Frontiers in Medicine

Jesús Barrio¹  Isabel Vera²  Manuel Barreiro-de Acosta³  Guillermo Alcaín⁴  Victor Morales⁵  Yamile Zabana⁶  Ruth De Francisco⁹  Eva Iglesias^1,10  Eugeni Domènech^1,11  Míriam Mañosa^1,11  María Dolores Martín-Arranz^1,12  José Huguet^1,15  Fernando Bermejo^1,16  Luis Bujanda^1,17  Rubén Francés^1,18  Belén Herreros^1,19  Mercè Navarro^2,20  Javier P. Gisbert^2,21  Luis Fernández-Salazar^2,22  Noemí Manceñido^2,23  Mariam Aguas^2,24  Eva Sierra^2,25  Olga Merino^2,26  David Busquets^2,27  Daniel Carpio^2,28  Alfredo J. Lucendo^2,29  Lucía Madero^3,30  Eugenia Sánchez-Rodríguez^3,31  Joan Riera^3,32  Manuel Van Domselaar^3,33  Luisa De Castro^3,34  María Pilar Martínez-Montiel^3,35  Pilar Varela^3,36  Maia Bosca-Watts^3,37  Milagros Vela^3,38  Daniel Ginard^3,39  Marta Roldón^4,40  Cristina Rodríguez^4,41  Viviana Laredo^4,42  Fernando Muñoz^4,43  José Lázaro Pérez-Calle^4,44  Iago Rodríguez-Lago^4,46  Marta Piqueras^4,47  Oscar Roncero^4,48  Empar Sainz^4,49  Carmen Muñoz-Villafranca^5,50  Blau Camps^5,51  Rufo Lorente^5,52  Pedro Almela^5,53  Laura Ramos^5,55  Esther Hinojosa^5,56  Xavier Calvet^5,57  Ignacio Marín-Jiménez^5,58  Mónica Sierra^5,59  Eva Sesé^6,60  Montserrat Rivero^6,61  Federico Argüelles-Arias^6,62  Lara Arias^6,63  Ana Gutiérrez^6,64  Laura Sempere^6,65  Pedro Zapater^6,66  Roser Muñoz^6,67  David Olivares^6,68  María González-Vivó^6,69  Jordi Gordillo^7,70  Elena Ricart^7,71 

[1] 0Hospital Universitario Rio Hortega, Valladolid, Spain;0Servicio Aparato Digestivo, Hospital Universitario Puerta de Hierro, Madrid, Spain;0Servicio Aparato Digestivo, Hospital Universitario Santiago, Santiago de Compostela, Spain;0Servicio Medicina Digestiva, Hospital Clínico Virgen de la Victoria, Málaga, Spain;0Servicio Medicina Digestiva, Hospital General de Granollers, Barcelona, Spain;0Servicio Medicina Digestiva, Hospital Universitari Mútua Terrassa, Terrassa, Spain;0Servicio Medicina Digestiva, Hospital Universitario Reina Sofía, Córdoba, Spain;1Hepatic and Intestinal Immunobiology Group, Dpto. Medicina Clínica, Universidad Miguel Hernández, San Juan de Alicante, Spain;1Hospital Universitario Central de Asturias and ISPA, Oviedo, Spain;1Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain;1Servicio Aparato Digestivo, Hospital Universitari Germans Trias I Pujol, Badalona, Spain;1Servicio Medicina Digestiva, Hospital La Paz, Madrid, Spain;1Servicio Medicina Digestiva, Hospital Universitario Donostia, San Sebastián, Spain;1Servicio Medicina Digestiva, Hospital de Fuenlabrada, Fuenlabrada, Spain;2Consorcio Hospital General Universitario de Valencia, Valencia, Spain;2IIS Hospital La Paz IdiPaz-Madrid, Madrid, Spain;2Instituto Biodonostia, Universidad Pais Vasco, San Sebastián, Spain;2Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández, Elche, Spain;2Servicio Medicina Digestiva, Hospital Marina Baixa, Villajoyosa, Spain;2Servicio Medicina Digestiva, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain;2Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain;3Servicio Medicina Digestiva, Hospital Clínico de Valladolid, Madrid, Spain;3Servicio Medicina Digestiva, Hospital Infanta Sofía, Madrid, Spain;3Servicio Medicina Digestiva, Hospital Universitario La Fé, Valencia, Spain;3Servicio Medicina Digestiva, Hospital Universitario Miguel Servert, Zaragoza, Spain;3Servicio Medicina Digestiva, Hospital de Cruces, Bilbao, Spain;3Servicio Medicina Digestiva, Hospital de Girona Dr. Trueta/ICO, Girona, Spain;4Complejo Hospitalario Universitario Pontevedra, Pontevedra, Spain;4Servicio Medicina Digestiva, Hospital General Tomelloso, Ciudad Real, Spain;4Servicio Medicina Digestiva, Hospital General Universitario de Elche, Elche, Spain;4Servicio Medicina Digestiva, Hospital Universitario Ramón y Cajal, Madrid, Spain;4Servicio Medicina Digestiva, Hospital Universitario Son LLàtzer, Palma de Mallorca, Spain;4Servicio Medicina Digestiva, Hospital de Torrejón de Ardoz, Madrid, Spain;5Department of Gastroenterology, Xerencia Xestion Integrada de Vigo- SERGAS. IIS Galicia Sur. SERGAS-UVIG, Vigo, Spain;5Servicio Medicina Digestiva, Hospital 12 de Octubre, Madrid, Spain;5Servicio Medicina Digestiva, Hospital Cabueñes, Gijón, Spain;5Servicio Medicina Digestiva, Hospital Clínico Universitario de Valencia, Valencia, Spain;5Servicio Medicina Digestiva, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain;5Servicio Medicina Digestiva, Hospital Universitario Son Espases, Palma de Mallorca, Spain;6Servicio Cirugía General y del Aparato Digestivo, Hospital San Jorge, Huesca, Spain;6Servicio Medicina Digestiva, Complejo Hospitalario de Navarra, Pamplona, Spain;6Servicio Medicina Digestiva, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain;6Servicio Medicina Digestiva, Hospital Clínico Universitario Salamanca, Salamanca, Spain;6Servicio Medicina Digestiva, Hospital Universitario Fundación de Alcorcón, Madrid, Spain;6Servicio de Aparato Digestivo, Hospital Universitario de Galdakao, IIS Biocruces, Galdakao, Spain;7Facultad de Medicina, University of Deusto, Bilbao, Spain;7Servicio Medicina Digestiva, Consorci Sanitari Terrasa, Barcelona, Spain;7Servicio Medicina Digestiva, Hospital General La Mancha Centro, Ciudad Real, Spain;7Servicio Medicina Digestiva, Hospital Sant Joan de Déu - Althaia, Manresa, Spain;7Servicio Medicina Digestiva, Hospital Universitario de Basurto, Bilbao, Spain;7Servicio Medicina Digestiva, Hospital Universitario de Bellvitge, Barcelona, Spain;8Servicio Medicina Digestiva, Hospital General Ciudad Real, Ciudad Real, Spain;8Servicio Medicina Digestiva, Hospital General Universitario Castellón, Castellón de la Plana, Spain;8Servicio Medicina Digestiva, Hospital Gregorio Marañón, Madrid, Spain;8Servicio Medicina Digestiva, Hospital Universitario La Laguna, Santa Cruz Tenerife, Spain;8Servicio Medicina Digestiva, Hospital de Manises, Valencia, Spain;8Unitat Malalties Digestives, Hospital de Sabadell, Institut Universitari Parc Tauli, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain;9Gastroenterology Department, Instituto de Investigación Biomédica Gregorio Marañón IiSGM, Madrid, Spain;9Servicio Medicina Digestiva, Complejo Asistencial Universitario de León, León, Spain;9Servicio Medicina Digestiva, Hospital Arnau de Vilanova, Lleida, Spain;9Servicio Medicina Digestiva, Hospital Universitario Marqués de Valdecilla and IDIVAL, Santander, Spain;9Servicio Medicina Digestiva, Hospital Universitario Virgen Macarena, Sevilla, Spain;9Servicio Medicina Digestiva, Hospital Universitario de Burgos, Burgos, Spain;Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain;IIS Isabial, Hospital General Universitario Alicante, Alicante, Spain;Instituto IDIBE, Universidad Miguel Hernández, San Juan de Alicante, Spain;Servicio Medicina Digestiva, Hospital General Universitario Alicante, Alicante, Spain;Servicio Medicina Digestiva, Hospital Universitario Clínico San Carlos, Madrid, Spain;Servicio Medicina Digestiva, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain;Servicio Patología Digestiva, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain;Servicio de Medicina Digestiva Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain;Unidad Farmacología Clínica, Hospital General Universitario Alicante, Alicante, Spain;

关键词: immigrant;    phenotype;    biologics;    inflammatory bowel disease;    Crohn's disease;    ulcerative colitis;   

DOI  :  10.3389/fmed.2022.823900

来源: DOAJ

【 摘 要 】

BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients.ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses.ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

【 授权许可】

Unknown