Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics

Applied Sciences

Shivam Shukla¹  Naren Naik¹  Asima Pradhan²  Pankaj Singh²  Prabodh Pandey² 

[1] Center for Lasers and Photonics, Indian Institute of Technology Kanpur, Kanpur 208016, India;Department of Physics, Indian Institute of Technology Kanpur, Kanpur 208016, India;

关键词: optical parameters;    beveled fiber;    spatially resolved reflectance;    epithelial pre-cancer;    look-up table;   

DOI  :  10.3390/app10248836

来源: DOAJ

【 摘 要 】

Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data.

【 授权许可】

Unknown