Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis

CNS Oncology

Stephanie M Perkins¹  Emily C Merfeld²  Sonika Dahiya³ 

[1] Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110 USA;1Department of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110 USA;;2Department of Pathology &

关键词: astroblastoma;    brain tumor;    neuro-oncology;    pediatric oncology;    rare tumor;   

DOI  :  10.2217/cns-2017-0038

来源: DOAJ

【 摘 要 】

Aim: To evaluate the use of chemotherapy and radiation, and their outcomes for patients with astroblastoma. Patients & methods: This is a retrospective review of patients extracted from the National Cancer Database. We investigated overall survival (OS) using Kaplan–Meier curves. Cox proportional hazards models were used to correlate OS with risk variables and treatments. Results: OS at 5 years was 79.5%. Patients with high-grade tumors were more likely to receive chemotherapy and radiation. Patients with high-grade astroblastoma who did not receive adjuvant radiation had poor survival. Conclusion: Patients with astroblastoma should be treated with curative intent. Radiation is likely beneficial in high-grade astroblastoma. The exact role of radiation and chemotherapy following surgical resection warrant further investigation.

【 授权许可】

Unknown