Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability

Biosensors

Federica Fasani¹  Giuseppe Baselli¹  Francesca Baglio²  Laura Pelizzari²  Maria Marcella Laganಠ Marta Cazzoli² 

[1] Department of Electronics, Information, and Bioengineering, Politecnico di Milano, 20133 Milan, Italy;IRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, Italy;

关键词: arterovenous flow;    cerebrospinal fluid flow;    MRI;    beat-by-beat variability;    rehabilitation;    neurodegeneration;   

DOI  :  10.3390/bios12060417

来源: DOAJ

【 摘 要 】

Beat-by-beat variability (BBV) rhythms are observed in both cardiovascular (CV) and intracranial (IC) compartments, yet interactions between the two are not fully understood. Real-Time Phase-Contrast (RT-PC) MRI sequence was acquired for 30 healthy volunteers at 1st cervical level on a 3T scanner. The arterial (AF), venous (VF), and cerebrospinal fluid (CSF) flow (CSFF) were computed as velocity integrals over the internal carotid artery, internal jugular vein, and CSF. AF, VF, and CSFF signals were segmented in inspiration and expiration beats, to assess the respiration influence. Systolic and diastolic BBV, and heart period series underwent autoregressive power spectral density analysis, to evaluate the low-frequency (LF, Mayer waves) and high frequency (HF, respiratory waves) components. The diastolic VF had the largest BBV. LF power was high in the diastolic AF series, poor in all CSFF series. The pulse wave analyses revealed higher mean amplitude during inspiration. Findings suggests a possible role of LF modulation of IC resistances and propagation of HF waves from VF to AF and CCSF. PC-RT-MRI could provide new insight into the interaction between CV and IC regulation and pave the way for a detailed analysis of the cerebrovascular effects of varied respiration patterns due to exercise and rehabilitation.

【 授权许可】

Unknown