Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis

Clinical and Molecular Allergy

Christer Janson¹  Sulaf Mosa Issa²  Kosar Mohammad Ali²  Muaid Ismiel Aziz²  Kawa Amin²  Jonas Bystrom³  Huner Mohamed Hama Amieen⁴ 

[1] Department of Medical Science, Respiratory, Allergy and Sleep Research, Uppsala University;Department of Medicine and Microbiology/Immunology, College of Medicine, University of Sulaimani;Expermiental Medicine and Rheumatology, William Harvey Research Institute, Barts & The London, Queen Mary, University of London;Otolaryngology Center, Sulaimani Teaching Hospital;

关键词: Allergic rhinitis;    Immune system;    ECP;    IL-17;    IL-33;    IgE;   

DOI  :  10.1186/s12948-020-00117-6

来源: DOAJ

【 摘 要 】

Abstract Background The aim was to determine the level of inflammatory cytokines, eosinophil cationic protein and IgE in allergic rhinitis (AR) patients. Subjects and methods Blood samples were taken from 88 AR patients and 88 healthy controls (HC). Each sample was analysed for eosinophil counts by flow cytometry, IgE by ECLIA, ECP, IL-17, and IL-33 by using ELISA test. Results There was no significant difference between AR patients and the control group in age and gender. Levels of eosinophils, IgE, ECP, IL-17, IL-33 and the total symptom scores were significantly higher in AR patients than the HC (P = 0.0001). Serum ECP correlated with IL-17 (P = 0.041, r = 0.42), IL-33 (P = 0.0001, r = 080), and IgE levels (P = 0.017, r = 0.45) in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils (P = 0.026, r = 0.52), and IgE (P = 0.001, r = 0.60) in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient. Conclusions Patients with AR have significant higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used to in order to diagnose AR and to monitor disease. Inhibitory molecules to IL-17 and IL-33 may be considered as novel treatment strategies.

【 授权许可】

Unknown