Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients

Journal of Clinical Medicine

Joanna Kluz¹  Tomasz Francuz²  Adrian P. Kowalik³  Jacek Ziaja³  Dominika Bożek-Pająk³  Lech Cierpka³  Robert Król³  Jerzy Chudek⁴  Magdalena Krajewska⁵  Dorota Kamińska⁵  Mariusz Kusztal⁵  Piotr Kuczera⁶  Andrzej Więcek⁶  Aureliusz Kolonko⁶  Agata Kujawa-Szewieczek⁶  Aleksander J. Owczarek⁷  Piotr Choręza⁷ 

[1] Department of Angiology, Hypertension and Diabetology, University Clinical Hospital, 50-556 Wrocław, Poland;Department of Biochemistry, Medical University of Silesia, 40-752 Katowice, Poland;Department of General, Vascular and Transplant Surgery, Medical University of Silesia, 40-027 Katowice, Poland;Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, 40-027 Katowice, Poland;Department of Nephrology and Transplantation Medicine, Wrocław Medical University, 50-556 Wrocław, Poland;Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, Poland;Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, 40-752 Katowice, Poland;

关键词: arterial stiffness;    atherosclerosis;    intima-media thickness;    matrix metalloproteinases;    simultaneous pancreas kidney transplantation;    type 1 diabetes;   

DOI  :  10.3390/jcm10173800

来源: DOAJ

【 摘 要 】

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), and biomarkers of arterial wall calcification in T1D patients after SPK or kidney transplantation alone (KTA). In 39 SPK and 39 KTA adult patients of similar age, PWV, IMT, circulating matrix metalloproteinases (MMPs) and calcification biomarkers were assessed at median 83 months post transplantation. Additionally, carotid plaques were visualized and semi-qualitatively classified. Although PWV and IMT values were similar, the occurrence of atherosclerotic plaques (51.3 vs. 70.3%, p < 0.01) and calcified lesions (35.9 vs. 64.9%, p < 0.05) was lower in SPK patients. There were significantly lower concentrations of MMP-1, MMP-2, MMP-3, and osteocalcin in SPK subjects. Among the analyzed biomarkers, only logMMP-1, logMMP-2, and logMMP-3 concentrations were associated with log HbA_1c. Multivariate stepwise backward regression analysis revealed that MMP-1 and MMP-3 variability were explained only by log HbA_1c. Normal glucose metabolism achieved by SPK is followed by the favorable profile of circulating matrix metalloproteinases, which may reflect the vasoprotective effect of pancreas transplantation.

【 授权许可】

Unknown