ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature

Autopsy and Case Reports

Rakesh Kochhar¹  Saroj Kant Sinha¹  Kirti Gupta²  Kaniyappan Nambiyar²  Uma Debi³ 

[1] Postgraduate Institute of Medical Education and Research, Department of Gastroenterology, Chandigarh, India;Postgraduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India;Postgraduate Institute of Medical Education and Research, Department of Radiodiagnosis and imaging, Chandigarh, India;

关键词: Lymphoma;    Large-cell;    Anaplastic;    Anaplastic lymphoma kinase;    Heart;    Thymus Gland;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)- positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Extensive cardiac infiltration with the near replacement of the myocardial wall by the neoplastic cells was observed. A total of nine isolated case reports of anaplastic large cell lymphoma with cardiac involvement were found in the English-language literature, and a widespread cardiac and thymic infiltration by the systemic ALK-positive anaplastic large cell lymphoma has not been documented. An incidental regenerative nodule was also identified in the liver. The patient died of pulmonary thromboembolism and cardiac arrest.

【 授权许可】

Unknown