Plant associated fungal endophytes as a source of natural bioactive compounds

Mycology

Santosh Kumar Singh¹  Priyanka Kumari Keshri¹  Ashish Verma¹  Nilesh Rai¹  Vibhav Gautam¹  Suvakanta Barik²  Pradeep Mishra³  Swapnil C. Kamble⁴ 

[1] Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University;Indian Institute of Technology Gandhinagar, Palaj;Karolinska Institute;Savitribai Phule Pune University;

关键词: fungal endophyte;    bioactive compound;    host endophytes relationship;    biological activity;   

DOI  :  10.1080/21501203.2020.1870579

来源: DOAJ

【 摘 要 】

Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds. Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds. Numerous bioactive compounds with antioxidant, antimicrobial, anticancer, and immunomodulatory properties are known to be derived from fungal endophytes. Bioinformatics tools along with the latest techniques such as metabolomics, next-generation sequencing, and metagenomics multilocus sequence typing can potentially fill the gaps in fungal endophyte research. The current review article focuses on bioactive compounds derived from plant-associated fungal endophytes and their pharmacological importance. We conclude with the challenges and opportunities in the research area of fungal endophytes.

【 授权许可】

Unknown