Impaired perception of illusory contours and cortical hypometabolism in patients with Parkinson’s disease

NeuroImage: Clinical

Yoshiyuki Hosokai¹  Kazumi Hirayama²  Kyoko Suzuki³  Yoichi Sawada⁴  Etsuro Mori⁵  Atsushi Takeda⁵  Yoshiyuki Nishio⁵  Nobuhito Abe⁶  Toshiyuki Ishioka⁷ 

[1] Corresponding author at: Department of Occupational Therapy, School of Health and Social Services, Saitama Prefectural University 820 San-Nomiya, Koshigaya, Saitama 343-8540, Japan.;Department of Behavioral Neurology and Cognitive Neuroscience, Graduate School of Medicine, Tohoku University, Japan;Department of Occupational Therapy, Yamagata Prefectural University of Health Science, Japan;Department of Radiological Sciences, International University of Health and Welfare, Japan;Department of Behavioral Neurology and Cognitive Neuroscience, Graduate School of Medicine, Tohoku University, Japan;Department of Neurology, Sendai Nishitaga Hospital, Japan;Department of Occupational Therapy, School of Health and Social Services, Saitama Prefectural University, Japan;

关键词: Perception;    Illusory contours;    Parkinson's disease;    Lateral occipital complex;   

DOI  :  

来源: DOAJ

【 摘 要 】

Neuroimaging evidence suggests that areas of the higher-order visual cortex, including the lateral occipital complex (LOC), are engaged in the perception of illusory contours; however, these findings remain unsubstantiated by human lesion data. Therefore, we assessed the presentation time necessary to perceive two types of illusory contours formed by Kanizsa figures or aligned line ends in patients with Parkinson's disease (PD). Additionally, we used 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to measure regional cerebral glucose metabolism in PD patients. Although there were no significant differences in the stimulus durations required for perception of illusory contours formed by aligned line ends between PD patients and controls, PD patients required significantly longer stimulus durations for the perception of Kanizsa illusory figures. Difficulty in perceiving Kanizsa illusory figures was correlated with hypometabolism in the higher-order visual cortical areas, including the posterior inferior temporal gyrus. These findings indicate an association between dysfunction in the posterior inferior temporal gyrus, a region corresponding to a portion of the LOC, and impaired perception of Kanizsa illusory figures in PD patients.

【 授权许可】

Unknown