Factors Predicting Pathological Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer: The Experience of a Single Institution with 269 Patients (STONE-01)

Cancers

Marco Caricato¹  Damiano Caputo²  Alessandro Coppola²  Roberto Coppola²  Luca E. Trodella³  Gabriele D’Ercole³  Pasquale Trecca³  Edy Ippolito³  Sara Ramella³  Michele Fiore³  Gian M. Petrianni³  Rolando M. D’Angelillo⁴ 

[1] Department of Colorectal Surgery, Campus Bio-Medico University, 00128 Rome, Italy;Department of General Surgery, Campus Bio-Medico University, 00128 Rome, Italy;Department of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy;Department of Radiation Oncology, University “Tor Vergata”, 00133 Rome, Italy;

关键词: rectal cancer;    chemoradiation;    predictive factors;    response;   

DOI  :  10.3390/cancers13236074

来源: DOAJ

【 摘 要 】

Aims: The aim of this study was to define a potential benefit of pathological complete response rate (pCR) and downstaging rate after neoadjuvant chemoradiotherapy (CRT) in relation to treatment and patient factors in locally advanced rectal cancer. Methods: We performed a retrospective cohort study. Patients were divided according to chemotherapy regimens concurrent to radiotherapy (1-drug vs. 2-drug) and according to the time interval between the end of CRT and surgery (≤8 weeks vs. >8 weeks), as well as in relation to specific relevant clinical factors. Logistic regression was used to estimate the independent factors for pCR and downstaging. Results: 269 patients were eligible for this study. Overall, pCR and downstaging rates were 26% and 75.4%, respectively. Univariate analysis showed that female gender (p = 0.01) and time to surgery >8 weeks (p = 0.04) were associated with pCR; age > 70 years (p = 0.05) and time to surgery >8 weeks (p = 0.002) were correlated to downstaging. At multivariate analysis, interval time to surgery of >8 weeks was the only independent factor for both pCR and downstaging (p = 0.02; OR: 0.5, CI: 0.27–0.93 and p = 0.003; OR: 0.42, CI: 0.24–0.75, respectively). Conclusions: This study indicates that, in our population, an interval time to surgery of >8 weeks is an independent significant factor for pCR and downstaging. Further prospective studies are needed to define the best interval time.

【 授权许可】

Unknown