Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report

Brain Sciences

Dai Suzuki¹  Tomosuke Nakano¹  Motohiro Okada¹  Eishi Motomura¹  Toshiki Hasegawa¹ 

[1] Department of Neuropsychiatry, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan;

关键词: amantadine;    carbon monoxide poisoning;    delayed neuropsychiatric sequelae;    nmda-r antagonist;   

DOI  :  10.3390/brainsci9110292

来源: DOAJ

【 摘 要 】

Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and fecal/urine incontinence, after remission of acute CO poisoning. Furthermore, he showed confusion, with disorientation in terms of time and space. All symptoms, including cognitive impairment, were dramatically improved by amantadine monotherapy. The present case illustrates the possibility of amantadine treatment for cognitive impairment as well as Parkinsonism induced by CO poisoning.

【 授权许可】

Unknown