The Role of Beclin 1-Dependent Autophagy in Cancer

Biology

Silvia Vega-Rubín-de-Celis¹ 

[1] Institute for Cell Biology (Tumorforschung), University Hospital Essen, 45122 Essen, Germany;

关键词: beclin 1;    autophagy;    cancer;   

DOI  :  10.3390/biology9010004

来源: DOAJ

【 摘 要 】

Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or exercising. Autophagy also plays a role in cancer, although its precise function in each cancer type is still obscure, and whether autophagy plays a protecting (through the clearing of damaged organelles and protein aggregates and preventing DNA damage) or a promoting (by fueling the already stablished tumor) role in cancer remains to be fully characterized. Beclin 1, the mammalian ortholog of yeast Atg6/Vps30, is an essential autophagy protein and has been shown to play a role in tumor suppression. Here, an update of the tumorigenesis regulation by Beclin 1-dependent autophagy is provided.

【 授权许可】

Unknown