期刊论文详细信息
Frontiers in Cardiovascular Medicine
Risk Factors Associated With Bleeding in Children With Cardiac Disease Receiving Extracorporeal Membrane Oxygenation: A Multi-Center Data Linkage Analysis
Asavari Kamerkar1  Josh Koch2  Joseph Kohne3  Renee Willett4  Peta M. A. Alexander6  Adam S. Himebauch7  Margaret Lewen8  Rod Ghassemzadeh8  Heidi J. Dalton9  Katherine Cashen1,10  Stephen J. Dolgner1,11  David K. Bailly1,12  Ashish A. Ankola1,13  Neeraj Srivastava1,14  Myke Federman1,14  Ron W. Reeder1,15 
[1] 0Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States;1Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ, United States;2Department of Pediatrics, University of Michigan, Ann Arbor, MI, United States;3Department of Pediatrics, Children's National Hospital, Washington, DC, United States;4Department of Cardiology, Boston Children's Hospital, Boston, MA, United States;5Department of Pediatrics and Harvard Medical School, Boston, MA, United States;Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA, United States;Department of Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States;Department of Pediatrics and Heart and Vascular Institute, Inova Fairfax Hospital, Fall Church, VA, United States;Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, United States;Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, TX, United States;Department of Pediatrics, Division of Pediatric Critical Care, University of Utah, Salt Lake City, UT, United States;Department of Pediatrics, Divisions of Critical Care and Cardiology, Baylor College of Medicine, Houston, TX, United States;Department of Pediatrics, Mattel Children's Hospital UCLA, Los Angeles, CA, United States;Department of Pediatrics, University of Utah, Salt Lake City, UT, United States;
关键词: extracorporeal membrane oxygenation;    bleeding;    pediatric;    cardiac;    anticoagulation;   
DOI  :  10.3389/fcvm.2021.812881
来源: DOAJ
【 摘 要 】

Background: Bleeding is a common complication of extracorporeal membrane oxygenation (ECMO) for pediatric cardiac patients. We aimed to identify anticoagulation practices, cardiac diagnoses, and surgical variables associated with bleeding during pediatric cardiac ECMO by combining two established databases, the Collaborative Pediatric Critical Care Research Network (CPCCRN) Bleeding and Thrombosis in ECMO (BATE) and the Extracorporeal Life Support Organization (ELSO) Registry.Methods: All children (<19 years) with a primary cardiac diagnosis managed on ECMO included in BATE from six centers were analyzed. ELSO Registry criteria for bleeding events included pulmonary or intracranial bleeding, or red blood cell transfusion >80 ml/kg on any ECMO day. Bleeding odds were assessed on ECMO Day 1 and from ECMO Day 2 onwards with multivariable logistic regression.Results: There were 187 children with 114 (61%) bleeding events in the study cohort. Biventricular congenital heart disease (94/187, 50%) and cardiac medical diagnoses (75/187, 40%) were most common, and 48 (26%) patients were cannulated directly from cardiopulmonary bypass (CPB). Bleeding events were not associated with achieving pre-specified therapeutic ranges of activated clotting time (ACT) or platelet levels. In multivariable analysis, elevated INR and fibrinogen were associated with bleeding events (OR 1.1, CI 1.0–1.3, p = 0.02; OR 0.77, CI 0.6–0.9, p = 0.004). Bleeding events were also associated with clinical site (OR 4.8, CI 2.0–11.1, p < 0.001) and central cannulation (OR 1.75, CI 1.0–3.1, p = 0.05) but not with cardiac diagnosis, surgical complexity, or cannulation from CPB. Bleeding odds on ECMO day 1 were increased in patients with central cannulation (OR 2.82, 95% CI 1.15–7.08, p = 0.023) and those cannulated directly from CPB (OR 3.32, 95% CI 1.02–11.61, p = 0.047).Conclusions: Bleeding events in children with cardiac diagnoses supported on ECMO were associated with central cannulation strategy and coagulopathy, but were not modulated by achieving pre-specified therapeutic ranges of monitoring assays.

【 授权许可】

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