Immunosuppression and cardiovascular dysfunction in patients with severe versus mild coronavirus disease 2019: a case series

Clinical & Translational Immunology

Qin Lai¹  Yinhua Fang²  Hehong Bao³  Gang Li⁴  Hejing Bao⁴  Yu Zheng⁵  Yanjun Hu⁶ 

[1] Department of Burn and Plastic Surgery Chongqing Three Gorges Central Hospital Chongqing China;Department of Nursing Chongqing Three Gorges Central Hospital Chongqing China;Department of Physical and Mental Rehabilitation Chongqing Three Gorges Central Hospital Chongqing China;Department of Radiation Oncology Department of Medical Oncology Chongqing UniversityThree Gorges Hospital/Chongqing Three Gorges Central Hospital Chongqing China;Pharmacy College Chengdu University of Traditional Chinese Medicine Chengdu China;Pharmacy Department Chongqing Three Gorges Central Hospital Chongqing China;

关键词: cardiovascular dysfunction;    COVID‐19;    immunology;    immunosuppression;    immunotherapy;    SARS‐CoV‐2;   

DOI  :  10.1002/cti2.1188

来源: DOAJ

【 摘 要 】

Abstract Objectives As coronavirus disease 2019 (COVID‐19) continues to spread globally, we aimed to describe and compare changes in the immune and cardiovascular systems of patients with mild versus severe COVID‐19 at different time points during the course of disease. Methods One hundred and one patients diagnosed with COVID‐19 who underwent serial peripheral blood collection and chest computed tomography (CT) imaging were enrolled in this study and grouped by the severity of their illness. Changes in the immune and cardiovascular systems were analysed and compared between groups. Results The study included 43 women and 58 men, with a median age of 45 years (interquartile range [IQR], 16–71). We identified spleen shrinkage in 27.7% of study patients. Ratios of spleen volume to patient (skin) volume were compared, with evidence that severe patients had more splenic shrinkage than mild patients. Lymphopenia was observed in 65.3% of patients, and 27.3% of patients had persistently low levels of lymphocytes after discharge. Tachycardia occurred mainly during the first 2 days of hospitalisation, with increases in creatine kinase–myocardial band levels in 10 (9.9%) patients and arrhythmias in 16 (15.8%) patients. Conclusions In addition to pulmonary manifestations, our study demonstrated that other organ systems can also be affected during COVID‐19 infection, with evidence of immunosuppression and cardiovascular dysfunction, which may contribute to increased mortality rates in critically ill COVID‐19 patients.

【 授权许可】

Unknown